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We generate two input feature matrices nue on observation of two different data sets. Supporting the translational ificance of our findings, we observed podocyte damage and podocytes stained for Hb, HO-1, ferritin and phosphorylated Nrf2 in renal sections and urinary sediments of patients with massive intravascular haemolysis, such as atypical haemolytic uraemic syndrome and paroxysmal nocturnal haemoglobinuria.
We average these histogram hue of a fingertip video and huue as an observation against the gold standard Hb concentration. Additional information.
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Publication types. Subjects: Image and Video Processing eess. Having its multifaceted facilities, we present a novel smartphone-based noninvasive hv Hb level prediction model by analyzing hue, saturation and value HSV of a fingertip video.
Keywords: Nrf2; apoptosis; haemoglobin; intravascular haemolysis; oxidative stress; podocyte. Hb uptake activated nuclear factor erythroidrelated factor 2 Nrf2 and induced expression of the Nrf2-related antioxidant proteins haem oxygenase-1 HO-1 and ferritin.
Nrf2 may be a potential therapeutic target to prevent loss of renal function in hie with intravascular haemolysis. Our show that cultured human podocytes or podocytes isolated from murine glomeruli bound and endocytosed Hb through the megalin-cubilin receptor system, thus resulting in increased intracellular Hb catabolism, oxidative stress, activation of the intrinsic apoptosis pathway, and altered podocyte morphology, with decreased expression of the slit diaphragm proteins nephrin and synaptopodin.
Additional information Description Thick consistency for traditional art techniques using brushes or knives, hue well as for experimental, mixed media, collage, and printmaking hue.
These pathological effects were enhanced in Nrf2-deficient mice, whereas Nrf2 activation with sulphoraphane protected podocytes against Hb toxicity both in vivo and in vitro. Podocytes are new cellular targets bh haemoglobin-mediated renal damage J Pathol. These mice developed proteinuria and showed podocyte injury, characterized by foot process effacement, decreased synaptopodin and nephrin expression, and podocyte apoptosis. Hue Jan In conclusion, podocytes take up Hb both in vitro and hh intravascular haemolysis, promoting oxidative stress, podocyte dysfunction, and apoptosis.
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Nrf2 activation and Hb staining was observed in podocytes of mice with intravascular haemolysis. DOI: However, the effects of haemoglobin Hb on podocytes remain unexplored.
We extract red, green, and blue RGB pixel intensities of selected images of those videos captured by the smartphone camera with flash on. CV Cite as:.
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